H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine

被引：17

作者：

Szabo, Piroska E. ^{[1
]}

Pfeifer, Gerd P. ^{[2
]}

机构：

[1] City Hope 1500, Dept Mol & Cellular Biol, Beckman Res Inst, Duarte, CA 91010 USA

[2] City Hope 1500, Dept Canc Biol, Beckman Res Inst, Duarte, CA 91010 USA

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2012年 / 4卷 / 06期

关键词：

IMPRINTING CONTROL REGIONS; EMBRYONIC STEM-CELLS; DNA METHYLATION; PATERNAL GENOME; EFFECT GENE; DEMETHYLATION; EMBRYOGENESIS; MAINTAINS; CHROMATIN; ZFP57;

D O I：

10.1093/jmcb/mjs038

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus. Recent work has shown that the maternal genome is protected from this remodeling step by an interaction between a modified histone, H3K9me2, and the oocyte-derived factor, PGC7, to prevent oxidation of the maternal DNA by the Tet3 5-methylcytosine oxidase.

引用

页码：427 / 429

页数：3

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