Scope of the intramolecular titanocene-catalyzed Pauson-Khand type reaction

被引：113

作者：

Hicks, FA ^{[1
]}

Kablaoui, NM ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 25期

关键词：

D O I：

10.1021/ja990682u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pauson-Khand type conversion of enynes to bicyclic cyclopentenones employing the commercially available precatalyst titanocene dicarbonyl is described. This methodology shows excellent functional group tolerance for a group 4 metallocene-catalyzed process. The scope and limitations of this cyclization with respect to 1,6-, 1,7- and 1,8-enynes with a variety of terminal alkyne substituents, chiral enynes, and enynes containing substituted olefins are described in detail. A mechanism involving carbonylation of an intermediate titanacyclopentene has been proposed.

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页码：5881 / 5898

页数：18

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