Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

被引：525

作者：

Hessel, Volker ^{[1
]}

Kralisch, Dana ^{[2
]}

Kockmann, Norbert ^{[3
]}

Noel, Timothy ^{[1
]}

Wang, Qi ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands

[2] Univ Jena, Inst Tech Chem & Environm Chem, D-07743 Jena, Germany

[3] Tech Univ Dortmund, D-44227 Dortmund, Germany

来源：

CHEMSUSCHEM | 2013年 / 6卷 / 05期

基金：

欧洲研究理事会;

关键词：

flow chemistry; green chemistry; microreactors; novel process windows; process intensification; INTEGRATED MICROREACTOR SYSTEM; PHASE CATALYTIC-REACTIONS; KOLBE-SCHMITT SYNTHESIS; LIFE-CYCLE ASSESSMENT; MICROFABRICATED MULTIPHASE REACTORS; SELECTIVE DIRECT FLUORINATION; FASTENING PROCESS-DEVELOPMENT; MICRO PROCESS TECHNOLOGY; HIGH-PRESSURE; PROCESS INTENSIFICATION;

D O I：

10.1002/cssc.201200766

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel Process Windows make use of process conditions that are far from conventional practices. This involves the use of high temperatures, high pressures, high concentrations (solvent-free), new chemical transformations, explosive conditions, and process simplification and integration to boost synthetic chemistry on both the laboratory and production scale. Such harsh reaction conditions can be safely reached in microstructured reactors due to their excellent transport intensification properties. This Review discusses the different routes towards Novel Process Windows and provides several examples for each route grouped into different classes of chemical and process-design intensification.

引用

页码：746 / 789

页数：44

共 321 条

[51]

Bourne RA., 2009, ANGEW CHEM, V121, P5426, DOI [10.1002/ange.200901731, DOI 10.1002/ANGE.200901731]

[52]

Braune S, 2009, CHIM OGGI, V27, P26

[53] One-pot multi-step synthesis: a challenge spawning innovation [J].

Broadwater, SJ ;

Roth, SL ;

Price, KE ;

Kobaslija, M ;

McQuade, DT .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, 3 (16) :2899-2906

[54] Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor [J].

Brocklehurst, Cara E. ;

Lehmann, Hansjorg ;

La Vecchia, Luigi .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (06) :1447-1453

[55]

Buchwald, 2008, ANGEW CHEM, V120, P183

[56] Process intensification: operating characteristics of rotating packed beds - determination of liquid hold-up for a high-voidage structured packing [J].

Burns, JR ;

Jamil, JN ;

Ramshaw, C .

CHEMICAL ENGINEERING SCIENCE, 2000, 55 (13) :2401-2415

[57] Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment [J].

Cantillo, David ;

Sheibani, Hassan ;

Kappe, C. Oliver .

JOURNAL OF ORGANIC CHEMISTRY, 2012, 77 (05) :2463-2473

[58] Preparation of biodiesel from soybean oil using supercritical methanol and co-solvent [J].

Cao, WL ;

Han, HW ;

Zhang, JC .

FUEL, 2005, 84 (04) :347-351

[59] What is a green solvent?: A comprehensive framework for the environmental assessment of solvents [J].

Capello, Christian ;

Fischer, Ulrich ;

Hungerbuehler, Konrad .

GREEN CHEMISTRY, 2007, 9 (09) :927-934

[60] Large-scale oxidations in the pharmaceutical industry [J].

Caron, Stephane ;

Dugger, Robert W. ;

Ruggeri, Sally Gut ;

Ragan, John A. ;

Ripin, David H. Brown .

CHEMICAL REVIEWS, 2006, 106 (07) :2943-2989

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