The human cerebrospinal fluid metabolome

被引：256

作者：

Wishart, David S. ^{[1
,4
,5
]}

Lewis, Michael J. ^{[1
]}

Morrissey, Joshua A. ^{[1
]}

Flegel, Mitchel D. ^{[1
]}

Jeroncic, Kevin ^{[1
]}

Xiong, Yeping ^{[2
]}

Cheng, Dean ^{[1
]}

Eisner, Roman ^{[1
]}

Gautam, Bijaya ^{[1
]}

Tzur, Dan ^{[1
]}

Sawhney, Summit ^{[4
]}

Bamforth, Fiona ^{[3
]}

Greiner, Russ ^{[1
]}

Li, Liang ^{[2
]}

机构：

[1] Univ Alberta, Dept Comp Sci, Edmonton, AB T6G 2E8, Canada

[2] Univ Alberta, Dept Chem, Edmonton, AB T6G 2E8, Canada

[3] Univ Alberta, Dept Clin Lab Med, Edmonton, AB T6G 2E8, Canada

[4] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E8, Canada

[5] Natl Inst Nanotechnol, Edmonton, AB T6G 2E8, Canada

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 871卷 / 02期

关键词：

cerebrospinal fluid; CSF; metabolome; metabolomics; nuclear magnetic resonance; mass spectrometry;

D O I：

10.1016/j.jchromb.2008.05.001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid (CSF). As part of our effort to systematically characterize the human metabolome we have chosen to characterize CSF as the first biofluid to be intensively scrutinized. In doing so, we combined comprehensive NMR, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) Fourier transform-mass spectrometry (FTMS) methods with computer-aided literature mining to identify and quantify essentially all of the metabolites that can be commonly detected (with today's technology) in the human CSF metabolome. Tables containing the compounds, concentrations, spectra, protocols and links to disease associations that we have found for the human CSF metabolome are freely available at http://www.csfmetabolome.ca. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：164 / 173

页数：10

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