Mechanistic insights into glycosidase chemistry

被引：329

作者：

Vocadlo, David J. ^{[1
]}

Davies, Gideon J. ^{[2
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[2] Univ York, Dept Chem, Struct Biol Lab, York YO10 5YW, N Yorkshire, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 05期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.cbpa.2008.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.

引用

页码：539 / 555

页数：17

共 120 条

[1] Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase [J].

Amaya, MF ;

Watts, AG ;

Damager, I ;

Wehenkel, A ;

Nguyen, T ;

Buschiazzo, A ;

Paris, G ;

Frasch, AC ;

Withers, SG ;

Alzari, PM .

STRUCTURE, 2004, 12 (05) :775-784

[2] Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin [J].

Andersen, Ole A. ;

Nathubhai, Amit ;

Dixon, Mark J. ;

Eggleston, Ian M. ;

van Aalten, Daan M. F. .

CHEMISTRY & BIOLOGY, 2008, 15 (03) :295-301

[3] Three-way stabilization of the covalent intermediate in amylomaltase, an α-amylase-like transglycosylase [J].

Barends, Thomas R. M. ;

Bultema, Jelle B. ;

Kaper, Thijs ;

van der Maarel, Marc J. E. C. ;

Dijkhuizen, Lubbert ;

Dijkstra, Bauke W. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (23) :17242-17249

[4] ISOLATION AND STRUCTURE OF A TRYPTIC GLYCOPEPTIDE FROM THE ACTIVE-SITE OF BETA-GLUCOSIDASE A3 FROM ASPERGILLUS-WENTII [J].

BAUSE, E ;

LEGLER, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 626 (02) :459-465

[5] THERMODYNAMICS OF INHIBITOR BINDING TO MUTANT FORMS OF GLUCOAMYLASE FROM ASPERGILLUS-NIGER DETERMINED BY ISOTHERMAL TITRATION CALORIMETRY [J].

BERLAND, CR ;

SIGURSKJOLD, BW ;

STOFFER, B ;

FRANDSEN, TP ;

SVENSSON, B .

BIOCHEMISTRY, 1995, 34 (32) :10153-10161

[6] Transition state analysis using multiple kinetic isotope effects: Mechanisms of enzymatic and non-enzymatic glycoside hydrolysis and transfer [J].

Berti, PJ ;

Tanaka, KSE .

ADVANCES IN PHYSICAL ORGANIC CHEMISTRY, VOL 37, 2002, 37 :239-314

[7] Substrate distortion in the michaelis complex of Bacillus 1,3-1,4-β-glucanase -: Insight from first principles molecular dynamics simulations [J].

Biarnés, X ;

Nieto, J ;

Planas, A ;

Rovira, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (03) :1432-1441

[8] The conformational free energy landscape of β-D-glucopyranose. implications for substrate preactivation in β-glucoside hydrolases [J].

Biarnes, Xevi ;

Ardevol, Albert ;

Planas, Antoni ;

Rovira, Carme ;

Laio, Alessandro ;

Parrinello, Michele .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (35) :10686-10693

[9] A theoretical DFT investigation of the lysozyme mechanism: Computational evidence for a covalent intermediate pathway [J].

Bottoni, A ;

Miscione, GP ;

De Vivo, M .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 59 (01) :118-130

[10] Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid β-glucosidase -: Insights into the mechanism of chemical chaperone action in Gaucher disease [J].

Brumshtein, Boris ;

Greenblatt, Harry M. ;

Butters, Terry D. ;

Shaaltiel, Yoseph ;

Aviezer, David ;

Silman, Israel ;

Futerman, Anthony H. ;

Sussman, Joel L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (39) :29052-29058

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