Mechanistic insights into glycosidase chemistry

被引：329

作者：

Vocadlo, David J. ^{[1
]}

Davies, Gideon J. ^{[2
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[2] Univ York, Dept Chem, Struct Biol Lab, York YO10 5YW, N Yorkshire, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 05期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.cbpa.2008.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.

引用

页码：539 / 555

页数：17

共 120 条

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