Transcription factor haploinsufficiency: when half a loaf is not enough

被引:168
作者
Seidman, JG
Seidman, C
机构
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] Howard Hughes Med Inst, Boston, MA USA
[3] Brigham & Womens Hosp, Div Cardiol, Boston, MA 02115 USA
关键词
D O I
10.1172/JC1200215043
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:451 / 455
页数:5
相关论文
共 14 条
[1]  
Blanchard EM, 1997, CIRC RES, V81, P1005
[2]   A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease [J].
Bruneau, BG ;
Nemer, G ;
Schmitt, JP ;
Charron, F ;
Robitaille, L ;
Caron, S ;
Conner, DA ;
Gessler, M ;
Nemer, M ;
Seidman, CE ;
Seidman, JG .
CELL, 2001, 106 (06) :709-721
[3]   Killing the messenger: new insights into nonsense-mediated mRNA decay [J].
Byers, PH .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (01) :3-6
[4]   Period of processing on serial production line, optimal scheduling and application [J].
Chen, WD ;
Xu, J ;
Liang, QH .
DISCRETE EVENT DYNAMIC SYSTEMS-THEORY AND APPLICATIONS, 1999, 9 (01) :9-21
[5]   Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation [J].
Hiroi, Y ;
Kudoh, S ;
Monzen, K ;
Ikeda, Y ;
Yazaki, Y ;
Nagai, R ;
Komuro, I .
NATURE GENETICS, 2001, 28 (03) :276-280
[6]   The T/ebp null mouse thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary [J].
Kimura, S ;
Hara, Y ;
Pineau, T ;
FernandezSalguero, P ;
Fox, CH ;
Ward, JM ;
Gonzalez, FJ .
GENES & DEVELOPMENT, 1996, 10 (01) :60-69
[7]  
Kirby ML, 1997, DEV DYNAM, V208, P34, DOI 10.1002/(SICI)1097-0177(199701)208:1<34::AID-AJA4>3.0.CO
[8]  
2-2
[9]   Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency [J].
Krude, H ;
Schütz, B ;
Biebermann, H ;
von Moers, A ;
Schnabel, D ;
Neitzel, H ;
Tönnies, H ;
Weise, D ;
Lafferty, A ;
Schwarz, S ;
DeFelice, M ;
von Deimling, A ;
van Landeghem, F ;
DiLauro, R ;
Grüters, A .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (04) :475-480
[10]  
MCKUSICK VA, 2002, OMIM ONLINE MENDELIA