Chromatin dynamics during cellular reprogramming

被引：280

作者：

Apostolou, Effie ^{[1
,2
,3
,4
,5
]}

Hochedlinger, Konrad ^{[1
,2
,3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[2] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[5] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

来源：

NATURE | 2013年 / 502卷 / 7472期

关键词：

PLURIPOTENT STEM-CELLS; MOUSE SOMATIC-CELLS; GROUND-STATE PLURIPOTENCY; PRIMORDIAL GERM-CELLS; DNA DEMETHYLATION; HISTONE VARIANTS; SELF-RENEWAL; C-MYC; TRANSCRIPTION FACTORS; LINEAGE SPECIFIERS;

D O I：

10.1038/nature12749

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

引用

页码：462 / 471

页数：10

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