Ischemic stroke and neurogenesis in the subventricular zone

被引：153

作者：

Zhang, Rui Lan ^{[1
]}

Zhang, Zheng Gang ^{[1
]}

Chopp, Michael ^{[1
,2
]}

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI 48309 USA

来源：

NEUROPHARMACOLOGY | 2008年 / 55卷 / 03期

关键词：

ischemic stroke; subventricular zone; neurogenesis;

D O I：

10.1016/j.neuropharm.2008.05.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The subventricular zone (SVZ) of the lateral ventricle contains neural stem and progenitor cells that generate neuroblasts, which migrate to the olfactory bulb where they differentiate into interneurons. Ischemic stroke induces neurogenesis in the SVZ and these cells migrate to the boundary of the ischemic lesion. This article reviews current data on cytokinetics, signaling pathways and vascular niche that are involved in processes of proliferation, differentiation, and migration of neural progenitor cells after stroke. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：345 / 352

页数：8

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