Messenger RNA degradation: Beginning at the end

被引：70

作者：

van Hoof, A

Parker, R

机构：

[1] Univ Arizona, Howard Hughes Med Inst, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(02)00802-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.

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收藏

页码：R285 / R287

页数：3

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