Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury

被引：45

作者：

Fu-jiang, Cao ^{[1
]}

Shi-qing, Feng ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Orthopaed, Tianjin 300052, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2009年 / 122卷 / 02期

基金：

中国国家自然科学基金;

关键词：

umbilical cord; mesenchymal stem cells; spinal cord injuries; BONE-MARROW; IN-VITRO; DIFFERENTIATION; BLOOD; EXPRESSION; TRANSPLANTATION; WINGLESS; NEURONS;

D O I：

10.3760/cma.j.issn.0366-6999.2009.02.021

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury. Datasources Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline. Study selection Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose. Results Recent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies. Conclusions Human umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.

引用

页码：225 / 231

页数：7

共 53 条

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