Structural Analysis of Synthetic Polymer Mixtures Using Ion Mobility and Tandem Mass Spectrometry

被引:58
作者
Hilton, Gillian R. [2 ]
Jackson, Anthony T. [1 ]
Thalassinos, Konstantinos [2 ]
Scrivens, James H. [2 ]
机构
[1] AkzoNobel China Appl Res Grp, Shanghai 201600, Peoples R China
[2] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
关键词
D O I
10.1021/ac801716c
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Ion mobility (IM) combined with tandem mass spectrometry (MS/MS) has been employed to separate and differentiate between polyether oligomers with the same nominal molecular weights. Poly(ethylene glycol)s with the same nominal mass-to-charge ratio (m/z), but with differing structures, were separated using ion mobility. IMMS/MS data were able to aid identification of the backbone and end groups of the four individual polyethers in the two sets of isobaric mixtures. The MS/MS data from the resolved oligomers enabled a detailed structural characterization of the polyether mixtures to be completed in one experiment.
引用
收藏
页码:9720 / 9725
页数:6
相关论文
共 29 条
[21]   Tandem mass spectrometry characteristics of silver-cationized polystyrenes: Internal energy, size, and chain end versus backbone substituent effects [J].
Polce, Michael J. ;
Ocampo, Manuela ;
Quirk, Roderic P. ;
Leigh, Alyison M. ;
Wesdemiotis, Chrys .
ANALYTICAL CHEMISTRY, 2008, 80 (02) :355-362
[22]   An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument [J].
Pringle, Steven D. ;
Giles, Kevin ;
Wildgoose, Jason L. ;
Williams, Jonathan P. ;
Slade, Susan E. ;
Thalassinos, Konstantinos ;
Bateman, Robert H. ;
Bowers, Michael T. ;
Scrivens, James H. .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2007, 261 (01) :1-12
[23]   Peak deconvolution in high-field asymmetric waveform ion mobility spectrometry (FAIMS) to characterize macromolecular conformations [J].
Robinson, Errol W. ;
Sellon, Rachel E. ;
Williams, Evan R. .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2007, 259 (1-3) :87-95
[24]   DISSOCIATION CHARACTERISTICS OF [M+X](+) IONS (X=H, LI, K) FROM LINEAR AND CYCLIC POLYGLYCOLS [J].
SELBY, TL ;
WESDEMIOTIS, C ;
LATTIMER, RP .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (12) :1081-1092
[25]   Resolving oligomers from fully grown polymers with IMS-MS [J].
Trimpin, Sarah ;
Plasencia, Manolo ;
Isailovic, Dragan ;
Clemmer, David E. .
ANALYTICAL CHEMISTRY, 2007, 79 (21) :7965-7974
[26]   Charge-induced unfolding of multiply charged polyethylene glycol ions [J].
Ude, S ;
de la Mora, JF ;
Thomson, BA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (38) :12184-12190
[27]   CONFORMATION OF MACROMOLECULES IN THE GAS-PHASE - USE OF MATRIX-ASSISTED LASER-DESORPTION METHODS IN ION CHROMATOGRAPHY [J].
VON HELDEN, G ;
WYTTENBACH, T ;
BOWERS, MT .
SCIENCE, 1995, 267 (5203) :1483-1485
[28]   Mass spectrometry of synthetic polymers [J].
Weidner, Steffen M. ;
Trimpin, Sarah .
ANALYTICAL CHEMISTRY, 2008, 80 (12) :4349-4361
[29]   Conformations of alkali ion cationized polyethers in the gas phase: polyethylene glycol and bis[(benzo-15-crown-5)-15-ylmethyl] pimelate [J].
Wyttenbach, T ;
von Helden, G ;
Bowers, MT .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 1997, 165 :377-390