Use of Mendelian randomisation to assess potential benefit of clinical intervention

被引：220

作者：

Burgess, Stephen ^{[1
]}

Butterworth, Adam

Malarstig, Anders ^{[2
]}

Thompson, Simon G.

机构：

[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England

[2] Pfizer Global Res & Dev, Cambridge, England

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2012年 / 345卷

关键词：

OBESITY; STATINS; TRIALS; RISK; FTO;

D O I：

10.1136/bmj.e7325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mendelian randomisation is a technique for assessing causal associations in observational data. Genetic variants associated with the risk factor of interest are regarded in a similar way to random assignment in a clinical trial. The difference in the risk factor due to the genetic variation, however, is materially distinct from the change due to any proposed therapeutic intervention and so might affect the outcome differently. Consequently, it can be misleading to generalise the magnitude of a Mendelian randomisation estimate to the effect of a potential intervention on the risk factor in practice. Awareness of the limitations of such estimates is important for the use of Mendelian randomisation in target based drug development

引用

页数：6

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