Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

被引：90

作者：

Brennan, Paul ^{[1
]}

McKay, James ^{[1
]}

Moore, Lee ^{[2
]}

Zaridze, David ^{[3
]}

Mukeria, Anush ^{[3
]}

Szeszenia-Dabrowska, Neonilia ^{[4
]}

Lissowska, Jolanta ^{[5
,6
]}

Rudnai, Peter ^{[7
]}

Fabianova, Eleonora ^{[8
]}

Mates, Dana ^{[9
]}

Bencko, Vladimir ^{[10
]}

Foretova, Lenka ^{[11
]}

Janout, Vladimir ^{[12
]}

Chow, Wong-Ho ^{[2
]}

Rothman, Nathaniel ^{[2
]}

Chabrier, Amelie ^{[1
]}

Gaborieau, Valerie ^{[1
]}

Timpson, Nic ^{[13
]}

Hung, Rayjean J. ^{[1
,14
]}

Smith, George Davey ^{[13
]}

机构：

[1] Int Agcy Res Canc, Genet Epidemiol Grp, F-69008 Lyon, France

[2] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[3] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow, Russia

[4] Inst Occupat Med, Dept Epidemiol, Lodz, Poland

[5] Marie Sklodowska Curie Mem Canc Ctr, Warsaw, Poland

[6] Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland

[7] Natl Inst Environm Hlth, Budapest, Hungary

[8] Specialized Inst Hyg & Epidemiol, Banska Bystrica, Slovakia

[9] Inst Publ Hlth, Bucharest, Romania

[10] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague 2, Czech Republic

[11] Mazaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic

[12] Palacky Univ, Fac Med, Dept Prevent Med, CR-77147 Olomouc, Czech Republic

[13] MRC, Ctr Causal Analyses Translat Epidemiol, CAITE, Dept Social Med, Bristol, Avon, England

[14] Univ Toronto, Canc Care Ontario Res Chair, Samuel Lunenfeld Res Inst, Toronto, ON M5S 1A1, Canada

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2009年 / 38卷 / 04期

关键词：

Obesity; cancer; Mendelian randomization; EPIDEMIOLOGY;

D O I：

10.1093/ije/dyp162

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Methods To avoid these biases we used a Mendelian randomization approach incorporating an analysis of variants in the FTO gene that are strongly associated with BMI levels among 7000 subjects from a study of lung, kidney and upper-aerodigestive cancer. Results The FTO A allele which is linked with increased BMI was associated with a decreased risk of lung cancer (allelic odds ratio (OR) = 0.92, 95% confidence interval (CI) 0.84-1.00). It was also associated with a weak increased risk of kidney cancer, which was more apparent before the age of 50 (OR = 1.44, CI 1.09-1.90). Conclusion Our results highlight the potential for genetic variation to act as an unconfounded marker of environmentally modifiable factors, and offer the potential to obtain estimates of the causal effect of obesity. However, far larger sample sizes than studied here will be required to undertake this with precision.

引用

页码：971 / 975

页数：5

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