Nuclease activity of [Cu(sulfathiazolato)2(benzimidazole)2]2MeOH.: Synthesis, properties and crystal structure

被引：32

作者：

González-Alvarez, M

Alzuet, G

Borrás, J

Macías, B

del Olmo, M

Liu-González, M

Sanz, F

机构：

[1] Univ Valencia, Dept Quim Inorgan, E-46100 Burjassot, Spain

[2] Univ Valencia, Dept Bioquim, E-46100 Burjassot, Spain

[3] Univ Valencia, Dept Termol, E-46100 Burjassot, Spain

[4] Univ Salamanca, Dept Quim Inorgan, Salamanca 37007, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 89卷 / 1-2期

关键词：

Cu(sulfathiazolato)(2)(benzimidazole)(2)](2)MeOH; nuclease activity; copper (II); DNA; pUC18;

D O I：

10.1016/S0162-0134(01)00369-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH complex has been synthesised and characterised. It crystallises in the monoclinic system, space group C1cl, with unit cell dimensions a = 18.829(7) Angstrom, b = 12.206(3) Angstrom, c = 17.233(5) Angstrom, alpha = 90.06(2)degrees, beta = 97.28(3)degrees, gamma = 90.21(3)degrees and Z = 4. The geometry around the copper(II) ion is intermediate between tetrahedral and square planar. The complex produces cleavage of plasmid pUC18 in presence of reducing agents. The efficiency of cleavage reaction of the title compound with pUC18 and with different reducing agents follows the order ascorbate-H2O2>ascorbate>MPA>dithiothreitol>H2O2. (C) 2002 Elsevier Science Inc. All rights reserved.

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页码：29 / 35

页数：7

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