COORDINATION BEHAVIOR OF SULFATHIAZOLE - CRYSTAL-STRUCTURE OF [CU(SULFATHIAZOLE)(PY)(3)CL] SUPEROXIDE-DISMUTASE ACTIVITY

被引：70

作者：

CASANOVA, J

ALZUET, G

BORRAS, J

LATORRE, J

SANAU, M

机构：

[1] UNIV VALENCIA, FAC FARM, DEPT QUIM INORGAN, E-46100 BURJASSOT, SPAIN

[2] UNIV OVIEDO, DEPT QUIM FIS & ANALIT, E-33071 OVIEDO, SPAIN

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1995年 / 60卷 / 03期

关键词：

D O I：

10.1016/0162-0134(95)00022-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation, spectroscopic, magnetic properties, and crystal structure of [Cu(stz)(py)(3)Cl] (stz(-) stands for the deprotonated form of sulfathiazole, 4-amino-N-2-thiazolylbencenosulfonamide) are reported. Crystals are orthorhombic, space group Pbca, with cell constants a=15.834(2), b= 17.512(4), and c=18.79(2) Angstrom, and Z=8. The structure was solved and refined to R=0.041 (R(w)=0.040). The structure consists of mononuclear units linked via hydrogen bonds to form the tridimensional pyramid. The geometry of CuN3N*NCl chromophore is distorted square-pyramid. The superoxide-dismutase mimetic activity of the compound is measured and compared with those of the SOD enzyme, the free drug, and other related sulfathiazole complexes.

引用

页码：219 / 230

页数：12

共 43 条

[1] SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC PROPERTIES OF COPPER(II) COMPOUNDS CONTAINING NITROGEN SULFUR DONOR LIGANDS - THE CRYSTAL AND MOLECULAR-STRUCTURE OF AQUA[1,7-BIS(N-METHYLBENZIMIDAZOL-2'-YL)-2,6-DITHIAHEPTANE]COPPER(II) PERCHLORATE [J].