Self-aligning microfluidic interconnects for glass- and plastic-based microfluidic systems

被引:62
作者
Puntambekar, A [1 ]
Ahn, CH [1 ]
机构
[1] Univ Cincinnati, Dept Elect & Comp Engn & Comp Sci, Microsyst & BIOMEMS Lab, Cincinnati, OH 45221 USA
关键词
D O I
10.1088/0960-1317/12/1/306
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
In this work, we present novel self-aligning fluidic interconnection techniques with low dead volume and pressure drop for generic microfluidic systems and capillary electrophoresis chips. We have successfully designed, fabricated and characterized two self-aligning fluidic interconnection techniques in this work, both resulting in low dead volume and low pressure drop across the interconnects. The first technique is a serial assembly technique. in which each fluidic interconnect is assembled individually, exhibiting a pressure drop of 977 Pa (0.14 psi) at a flow rate of 100 mul min(-1). The second technique is a parallel assembly technique that is suitable for high-density interconnects with multi-stacked generic microfluidic systems, which has a pressure drop of 1024 Pa (0.15 psi) at a flow rate of 100 mul min(-1). Furthermore, the parallel assembly technique is ideally suited for plastic-based microfluidic systems. We have simulated the flow characteristics of these interconnection schemes and, based in part on the simulation results, we have designed the above interconnection schemes. We have also characterized these interconnects in terms of the physical robustness of the interconnection scheme. The serial interconnection scheme can theoretically withstand 2.6 MPa and the parallel interconnection scheme can withstand a theoretical maximum pressure of 6.6 MPa.
引用
收藏
页码:35 / 40
页数:6
相关论文
共 9 条
[1]  
AHN CH, 1998, P MICR TOT AN SYST 9, P225
[2]  
Freemantle M, 1999, CHEM ENG NEWS, V77, P27, DOI 10.1021/cen-v077n044.p027
[3]  
Han A., 2000, Proceedings IEEE Thirteenth Annual International Conference on Micro Electro Mechanical Systems (Cat. No.00CH36308), P414, DOI 10.1109/MEMSYS.2000.838553
[4]   Integrated plastic microftuidic devices with ESI-MS for drug screening and residue analysis [J].
Jiang, Y ;
Wang, PC ;
Locascio, LE ;
Lee, CS .
ANALYTICAL CHEMISTRY, 2001, 73 (09) :2048-2053
[5]  
Kovacs G.T., 1998, Micromachined Transducers Sourcebook
[6]   Microfabricated plastic chips by hot embossing methods and their applications for DNA separation and detection [J].
Lee, GB ;
Chen, SH ;
Huang, GR ;
Sung, WC ;
Lin, YH .
SENSORS AND ACTUATORS B-CHEMICAL, 2001, 75 (1-2) :142-148
[7]   Microfluidic plastic interconnects for multi-bioanalysis chip modules [J].
Man, PF ;
Jones, DK ;
Mastrangelo, CH .
MICROMACHINED DEVICES AND COMPONENTS III, 1997, 3224 :196-200
[8]  
Mourlas N., 1998, P MICR AN SYST, P27
[9]  
[No title captured]