Cytoplasmic diffusion: molecular motors mix it up

被引：193

作者：

Brangwynne, Clifford P. ^{[1
]}

Koenderink, Gijsje H. ^{[1
,2
,3
]}

MacKintosh, Frederick C. ^{[4
]}

Weitz, David A. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[3] FOM, Inst Atom & Mol Phys, Fdn Fundamental Res Matter, NL-1098 SJ Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Dept Phys & Astron, NL-1081 HV Amsterdam, Netherlands

来源：

JOURNAL OF CELL BIOLOGY | 2008年 / 183卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1083/jcb.200806149

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Random motion within the cytoplasm gives rise to molecular diffusion; this motion is essential to many biological processes. However, in addition to thermal Brownian motion, the cytoplasm also undergoes constant agitation caused by the activity of molecular motors and other nonequilibrium cellular processes. Here, we discuss recent work that suggests this activity can give rise to cytoplasmic motion that has the appearance of diffusion but is significantly enhanced in its magnitude and which can play an important biological role, particularly in cytoskeletal assembly.

引用

页码：583 / 587

页数：5

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