Tissue-resident macrophages

被引：1563

作者：

Davies, Luke C. ^{[1
]}

Jenkins, Stephen J. ^{[2
]}

Allen, Judith E. ^{[3
,4
]}

Taylor, Philip R. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Cardiff Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales

[2] Univ Edinburgh, Queens Med Res Inst, Med Res Council Ctr Inflammat Res, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland

[4] Univ Edinburgh, Inst Immunol & Infect Res, Sch Biol Sci, Edinburgh, Midlothian, Scotland

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 10期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

MARGINAL METALLOPHILIC MACROPHAGES; LANGERHANS CELLS; DENDRITIC CELL; APOPTOTIC CELLS; ALTERNATIVE ACTIVATION; PERITONEAL-MACROPHAGES; ALVEOLAR MACROPHAGES; ZONE MACROPHAGES; MYELOID CELLS; PPAR-GAMMA;

D O I：

10.1038/ni.2705

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the resolution of inflammation. Recent studies highlight marked heterogeneity in the origins of tissue macrophages that arise from hematopoietic versus self-renewing embryo-derived populations. We discuss the tissue niche-specific factors that dictate cell phenotype, the definition of which will allow new strategies to promote the restoration of tissue homeostasis. Understanding the mechanisms that dictate tissue macrophage heterogeneity should explain why simplified models of macrophage activation do not explain the extent of heterogeneity seen in vivo.

引用

页码：986 / 995

页数：10

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