Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy

被引：21

作者：

Chometon, Gretel ^{[1
]}

Jendrossek, Verena ^{[1
]}

机构：

[1] Univ Duisburg Essen, Dept Mol Cell Biol, Inst Cell Biol, D-45122 Essen, Germany

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2009年 / 11卷 / 02期

关键词：

Microenvironment; Treatment resistance; Radiotherapy; Reactive stroma; TRAIL RECEPTOR ANTIBODIES; LUNG-CANCER CELLS; PROSTATE-CANCER; DRUG-RESISTANCE; DNA-DAMAGE; PHASE-I; PANCREATIC-CANCER; ENDOTHELIAL-CELLS; BASEMENT-MEMBRANE; INDUCED APOPTOSIS;

D O I：

10.1007/s12094-009-0317-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The impact of a favourable microenvironment on tumour progression is a limiting factor for current tumour therapy protocols, as it contributes to the selection of resistant tumour cells. Apart from immune and inflammatory cells, the extracellular matrix, cancer-associated fibroblasts and vascular endothelial cells are crucial mediators of protective signals. An important research effort exposes potential environmental targets that may define new therapeutic strategies for solid tumours.

引用

页码：75 / 81

页数：7

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