A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods

被引：40

作者：

Ankri, Rinat

Peretz, Vital

Motiei, Menachem

Popovtzer, Rachela

Fixler, Dror ^{[1
]}

机构：

[1] Bar Ilan Univ, Fac Engn, IL-52900 Ramat Gan, Israel

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2012年 / 7卷

关键词：

molecular imaging; nanoparticles; EGFR targeted; tissues' optical properties; TISSUE OPTICAL-PROPERTIES; NANOPARTICLES; SPECTROSCOPY; ABSORPTION; MODEL; EXTRACTION; DIAGNOSIS; SHAPE; SIZE;

D O I：

10.2147/IJN.S28424

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection -measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.

引用

收藏

页码：449 / 455

页数：7

相关论文

共 29 条

[1]

Reflected light intensity profile of two-layer tissues: phantom experiments [J].

Ankri, Rinat ;

Taitelbaum, Haim ;

Fixler, Dror .

JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (08)

[2]

Baselga J, 2001, EUR J CANCER, V37, pS16

[3]

Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results [J].

Bigio, IJ ;

Bown, SG ;

Briggs, G ;

Kelley, C ;

Lakhani, S ;

Pickard, D ;

Ripley, PM ;

Rose, IG ;

Saunders, C .

JOURNAL OF BIOMEDICAL OPTICS, 2000, 5 (02) :221-228

[4]

Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents [J].

Chen, J ;

Saeki, F ;

Wiley, BJ ;

Cang, H ;

Cobb, MJ ;

Li, ZY ;

Au, L ;

Zhang, H ;

Kimmey, MB ;

Li, XD ;

Xia, YN .

NANO LETTERS, 2005, 5 (03) :473-477

[5]

A solid tissue phantom for photon migration studies [J].

Cubeddu, R ;

Pifferi, A ;

Taroni, P ;

Torricelli, A ;

Valentini, G .

PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (10) :1971-1979

[6]

Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths [J].

Dam, JS ;

Pedersen, CB ;

Dalgaard, T ;

Fabricius, PE ;

Aruna, P ;

Andersson-Engels, S .

APPLIED OPTICS, 2001, 40 (07) :1155-1164

[7]

Analytical solution for light propagation in a two-layer tissue structure with a tilted interface for breast imaging [J].

Das, Mini ;

Xu, Chen ;

Zhu, Quing .

APPLIED OPTICS, 2006, 45 (20) :5027-5036

[8]

A DIFFUSION-THEORY MODEL OF SPATIALLY RESOLVED, STEADY-STATE DIFFUSE REFLECTANCE FOR THE NONINVASIVE DETERMINATION OF TISSUE OPTICAL-PROPERTIES INVIVO [J].

FARRELL, TJ ;

PATTERSON, MS ;

WILSON, B .

MEDICAL PHYSICS, 1992, 19 (04) :879-888

[9]

Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy [J].

Gobin, Andre M. ;

Lee, Min Ho ;

Halas, Naomi J. ;

James, William D. ;

Drezek, Rebekah A. ;

West, Jennifer L. .

NANO LETTERS, 2007, 7 (07) :1929-1934

[10]

Near-infrared fluorescence: application to in vivo molecular imaging [J].

Hilderbrand, Scott A. ;

Weissleder, Ralph .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (01) :71-79