Modulation of membrane traffic by mechanical stimuli

被引:214
作者
Apodaca, G
机构
[1] Univ Pittsburgh, Renal Electrolyte Div, Lab Epithelial Cell Biol, Dept Med, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA
关键词
membrane tension; stretch; mechanical forces; exocytosis; endocytosis; secretion; cytoskeleton; mechanosensors; signal transduction;
D O I
10.1152/ajprenal.2002.282.2.F179
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
All cells experience and respond to mechanical stimuli, such as changes in plasma membrane tension, shear stress, hydrostatic pressure, and compression. This review is an examination of the changes in membrane traffic that occur in response to mechanical forces. The plasma membrane has an associated tension that modulates both exocytosis and endocytosis. As membrane tension increases, exocytosis is stimulated, which acts to decrease membrane tension. In contrast, increased membrane tension slows endocytosis, whereas decreased tension stimulates internalization. In most cases, secretion is stimulated by external mechanical stimuli. However, in some cells mechanical forces block secretion. External stimuli also enhance membrane and fluid endocytosis in several cell types. Transduction of mechanical stimuli into changes in exocytosis/endocytosis may involve the cytoskeleton, stretch-activated channels, integrins, phospholipases, tyrosine kinases, and cAMP.
引用
收藏
页码:F179 / F190
页数:12
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