Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

被引：27

作者：

Clayden, J

Stimson, CC

Keenan, M

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Eli Lilly & Co, Windlesham GU20 6PH, Surrey, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 13期

关键词：

D O I：

10.1039/b600181e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Directed metallation and sulfinylation yields sulfoxides which undergo ipso nucleophilic aromatic substitution with tertiary and secondary alkyllithiums, giving aromatic rings bearing alkyl groups generally incompatible with directed metallation methods and with regioselectivity complementary with classical Friedel-Crafts substitution.

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页码：1393 / 1394

页数：2

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