Virally mediated gene transfer to the vasculature

被引：6

作者：

Gunnett, CA ^{[1
]}

Heistad, DD

机构：

[1] Univ Iowa, Coll Med, Dept Internal Med, 340B EMRB, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Dept Pharmacol, Ctr Cardiovasc, Iowa City, IA 52242 USA

[3] Univ Iowa, Coll Med, VA Med Ctr, Iowa City, IA 52242 USA

来源：

MICROCIRCULATION | 2002年 / 9卷 / 01期

关键词：

adenoviruses; adeno-associated viruses; vectors gene therapy;

D O I：

10.1038/sj.mn.7800119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gene transfer technology provides valuable tools for the study of vascular biology. By using gene transfer, effects of specific gene products can be evaluated in a highly selective manner. In recent years. techniques used for gene transfer have been adapted for applications to blood vessels, including microvessels, both in vitro and in vivo. The purpose of this review is to provide a survey of published work in thiS field of investigation and to discuss advantages and limitations of current methods used for gene transfer to the vasculature.

引用

页码：23 / 33

页数：11

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