Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

被引：125

作者：

Allan, Phoebe K. ^{[1
]}

Wheatley, Paul S. ^{[1
]}

Aldous, David ^{[1
]}

Mohideen, M. Infas ^{[1
]}

Tang, Chiu ^{[2
]}

Hriljac, Joseph A. ^{[3
]}

Megson, Ian L. ^{[4
]}

Chapman, Karena W. ^{[5
]}

De Weireld, Guy ^{[6
]}

Vaesen, Sebastian ^{[6
]}

Morris, Russell E. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Diamond Light Source, Didcot OX11 0DE, Oxon, England

[3] Univ Birmingham, Sch Chem Sci, Birmingham B15 2TT, W Midlands, England

[4] Univ Highlands and Islands, Free Radical Res Facil, Inverness IV2 3BL, Scotland

[5] Argonne Natl Lab, Adv Photon Source, Xray Sci Div, Argonne, IL 60439 USA

[6] Univ Mons, Lab Thermodynam, Fac Polytech, B-7000 Mons, Belgium

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

PRESSURE GAS-ADSORPTION; NITRIC-OXIDE; CARBON-MONOXIDE; RELEASE; SITES; NO;

D O I：

10.1039/c2dt12069k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

引用

页码：4060 / 4066

页数：7