Molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans

被引:118
作者
Shaw, M
Cooper, L
Xu, X
Thompson, W
Krauss, S
Guan, Y
Zhou, N
Klimov, A
Cox, N
Webster, R
Lim, W
Shortridge, K
Subbarao, K
机构
[1] CDCP, Influenza Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA
[2] St Jude Childrens Res Hosp, Dept Virol & Mol Biol, Memphis, TN 38105 USA
[3] Univ Hong Kong, Dept Microbiol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
[4] Queen Marys Hosp, Govt Virus Unit, Hong Kong, Hong Kong, Peoples R China
关键词
avian influenza virus; phylogenetics; interspecies transmission; host range;
D O I
10.1002/jmv.2118
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In order to identify molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans, the internal genes from these viruses were compared to sequences from other avian and human influenza A isolates. Phylogenetically, each of the internal genes of all sixteen of the human H5N1 and both of the H9N2 isolates were closely related to one another and fell into a distinct clade separate from clades formed by the same genes of other avian and human viruses. All six internal genes were most closely related to those of avian isolates circulating in Asia, indicating that reassortment with human strains had not occurred for any of these 18 isolates. Amino acids previously identified as host-specific residues were predominantly avian in the human isolates although most of the proteins also contained residues observed previously only in sequences of human influenza viruses. For the majority of the nonglycoprotein genes, three distinct subgroups could be distinguished on bootstrap analyses of the nucleotide sequences, suggesting multiple introductions of avian virus strains capable of infecting humans. The shared nonglycoprotein gene constellations of the human H5N1 and H9N2 isolates and their detection in avian isolates only since 1997 when the first human infections were detected suggest that this particular gene combination may confer the ability to infect humans and cause disease. Published 2002 Wiley-Liss, Inc.(dagger)
引用
收藏
页码:107 / 114
页数:8
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