Phylogenetic perspectives in innate immunity

被引：2038

作者：

Hoffmann, JA ^{[1
]}

Kafatos, FC

Janeway, CA

Ezekowitz, RAB

机构：

[1] CNRS, Inst Mol & Cellular Biol, F-67084 Strasbourg, France

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

[3] Yale Univ, Immunobiol Sect, New Haven, CT 06520 USA

[4] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The concept of innate immunity refers to the first-line host defense that serves to Limit infection in the early hours after exposure to microorganisms, Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity;in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

引用

页码：1313 / 1318

页数：6

共 109 条

[1] Mechanisms of phagocytosis in macrophages
Aderem, A
Underhill, DM
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 593 - 623
[2] Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
Agrawal, A
Eastman, QM
Schatz, DG
[J]. NATURE, 1998, 394 (6695) : 744 - 751
[3] INCREASED SUSCEPTIBILITY TO INFECTION ASSOCIATED WITH ABNORMALITIES OF COMPLEMENT-MEDIATED FUNCTIONS AND OF THIRD COMPONENT OF COMPLEMENT (C3)
ALPER, CA
ABRAMSON, N
JOHNSTON, RB
JANDL, JH
ROSEN, FS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1970, 282 (07) : 349 - &
[4] BOVINE AND MOUSE SERUM BETA-INHIBITORS OF INFLUENZA-A VIRUSES ARE MANNOSE-BINDING LECTINS
ANDERS, EM
HARTLEY, CA
JACKSON, DC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4485 - 4489
[5] INFORMATION FOR THE DORSAL VENTRAL PATTERN OF THE DROSOPHILA EMBRYO IS STORED AS MATERNAL MESSENGER-RNA
ANDERSON, KV
NUSSLEINVOLHARD, C
[J]. NATURE, 1984, 311 (5983) : 223 - 227
[6] ANDERSON KV, 1986, GAMETOGENESIS EARLY, P177
[7] Signaling in plant-microbe interactions
Baker, B
Zambryski, P
Staskawicz, B
DineshKumar, SP
[J]. SCIENCE, 1997, 276 (5313) : 726 - 733
[8] Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution
Beamer, LJ
Carroll, SF
Eisenberg, D
[J]. SCIENCE, 1997, 276 (5320) : 1861 - 1864
[9] Malaria parasite development in mosquitoes
Beier, JC
[J]. ANNUAL REVIEW OF ENTOMOLOGY, 1998, 43 : 519 - 543
[10] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway
Belvin, MP
Anderson, KV
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 : 393 - 416

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