Phylogenetic perspectives in innate immunity

被引：2038

作者：

Hoffmann, JA ^{[1
]}

Kafatos, FC

Janeway, CA

Ezekowitz, RAB

机构：

[1] CNRS, Inst Mol & Cellular Biol, F-67084 Strasbourg, France

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

[3] Yale Univ, Immunobiol Sect, New Haven, CT 06520 USA

[4] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The concept of innate immunity refers to the first-line host defense that serves to Limit infection in the early hours after exposure to microorganisms, Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity;in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

引用

页码：1313 / 1318

页数：6

共 109 条

[11] Human enteric defensin genes: Chromosomal map position and a model for possible evolutionary relationships
Bevins, CL
Jones, DE
Dutra, A
Schaffzin, J
Muenke, M
[J]. GENOMICS, 1996, 31 (01) : 95 - 106
[12] BOMAN HG, 1995, ANNU REV IMMUNOL, V13, P61, DOI 10.1146/annurev.iy.13.040195.000425
[13] Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D
Botas, C
Poulain, F
Akiyama, J
Brown, C
Allen, L
Goerke, J
Clements, J
Carlson, E
Gillespie, AM
Epstein, C
Hawgood, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) : 11869 - 11874
[14] MOLECULAR-BASIS OF POLYMORPHISMS OF HUMAN-COMPLEMENT COMPONENT-C3
BOTTO, M
FONG, KY
SO, AK
KOCH, C
WALPORT, MJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) : 1011 - 1017
[15] Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
Braun, A
Hoffmann, JA
Meister, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) : 14337 - 14342
[16] BREY PT, 1997, MOL MECHANISMS IMMUN
[17] BROEKAERT WF, 1995, PLANT PHYSIOL, V108, P1353, DOI [10.1104/pp.108.4.1353, 10.1016/j.chiabu.2021.105188, 10.1016/j.coelec.2021.100721]
[18] Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
Chaudhary, PM
Ferguson, C
Nguyen, V
Nguyen, O
Massa, HF
Eby, M
Jasmin, A
Trask, BJ
Hood, L
Nelson, PS
[J]. BLOOD, 1998, 91 (11) : 4020 - 4027
[19] GENETIC SELECTION OF A PLASMODIUM-REFRACTORY STRAIN OF THE MALARIA VECTOR ANOPHELES-GAMBIAE
COLLINS, FH
SAKAI, RK
VERNICK, KD
PASKEWITZ, S
SEELEY, DC
MILLER, LH
COLLINS, WE
CAMPBELL, CC
GWADZ, RW
[J]. SCIENCE, 1986, 234 (4776) : 607 - 610
[20] Collectins and pulmonary host defense
Crouch, EC
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (02) : 177 - 201

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