Monoamine Oxidase Inhibitors and Neuroprotection: A Review

被引：42

作者：

Al-Nuaimi, Saleem K. ^{[1
]}

MacKenzie, Erin M. ^{[1
]}

Baker, Glen B. ^{[1
]}

机构：

[1] Univ Alberta, Dept Psychiat, Neurochem Res Unit, Edmonton, AB T6G 2G3, Canada

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2012年 / 19卷 / 06期

基金：

加拿大健康研究院;

关键词：

monoamine oxidase inhibitors; neuroprotection; monoamine oxidase; phenelzine; (-)-deprenyl; SENSITIVE AMINE OXIDASE; GAMMA-AMINOBUTYRIC-ACID; ANTI-PARKINSON DRUG; NEUROBLASTOMA SH-SY5Y CELLS; ALZHEIMERS-DISEASE BRAIN; PROTEIN-BOUND ACROLEIN; L-DEPRENYL PROTECTS; NF-KAPPA-B; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; CEREBRAL-ISCHEMIA;

D O I：

10.1097/MJT.0b013e31825b9eb5

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Monoamine oxidase inhibitors have been available for more than 50 years, initially developed as antidepressants but currently used in a variety of psychiatric and neurological conditions. There has been a recent surge of interest in monoamine oxidase inhibitors because of their reported neuroprotective and/or neurorescue properties. Interestingly, it seems that often these properties are independent of their ability to inhibit monoamine oxidase. This review article presents an overview of the neuroprotective/neurorescue properties of these multifaceted drugs and focuses on phenelzine, (-)-deprenyl, rasagiline, ladostigil, tranylcypromine, moclobemide, and clorgyline and their possible neuroprotective mechanisms.

引用

页码：436 / 448

页数：13

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