β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

被引：50

作者：

Anand, Resmi ^{[1
]}

Manoli, Francesco ^{[1
]}

Manet, Ilse ^{[1
]}

Daoud-Mahammed, Samia ^{[2
]}

Agostoni, Valentina ^{[2
]}

Gref, Ruxandra ^{[2
]}

Monti, Sandra ^{[1
]}

机构：

[1] CNR, ISOF, I-40129 Bologna, Italy

[2] Univ Paris 11, CNRS, UMR 8612, F-92296 Chatenay Malabry, France

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2012年 / 11卷 / 08期

关键词：

IN-VITRO MODEL; INCLUSION COMPLEXATION; CIRCULAR-DICHROISM; GAMMA-CYCLODEXTRIN; ANTHRACYCLINE ANTIBIOTICS; EVAPORATIVE PRECIPITATION; ANTITUMOR-ACTIVITY; DAUNORUBICIN; DISSOLUTION; ENHANCEMENT;

D O I：

10.1039/c2pp25014d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The association of doxorubicin (DOX) and artemisinin (ART) to a beta-CyD-epichlorohydrin crosslinked polymer (p beta-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer p beta-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame.

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页码：1285 / 1292

页数：8

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