Computational Analysis of Microrna Profiles and Their Target Genes Involved In Multidrug Resistance of Breast Cancer Cell

被引：1

作者：

Chen, Guoqing ^{[1
]}

Zhao, Zhiwei ^{[2
]}

机构：

[1] Wuhan Inst phys Educ, Dept Hlth Sci, Wuhan, Peoples R China

[2] Sichuan Univ, Dept Human Anat, Wuhan, Peoples R China

来源：

SMART MATERIALS AND NANOTECHNOLOGY IN ENGINEERING | 2012年 / 345卷

关键词：

MicroRNA; multidrug resistance; gene ontology; pathway analysis; breast cancer; AXON GUIDANCE MOLECULES; ANNOTATION; BIOLOGY;

D O I：

10.4028/www.scientific.net/AMR.345.304

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Multidrug resistance remains a major clinical obstacle to successful treatment of breast cancer and leads to poor prognosis for the patients. Recently studies have shown that microRNAs play an important role in breast cancer cell resistance to chemotherapeutic agents. In this study, microRNA expression profiles of MCF-7/AdrVp and MCF-7 were analyzed using microarray. Gene Ontology and pathways mapping tools were employed to analysis systemically the biological processes and signaling pathways affected by differential expression microRNAs. The results indicated that breast cancer cell resistant to chemotherapy was associated with a group of microRNAs. Gene Ontology and pathway mapping are valid and effective approach to analysis the function of microRNAs and the results could be a guideline for further investigation.

引用

页码：304 / +

页数：3

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