Identification of a population of sleep-active cerebral cortex neurons

被引：126

作者：

Gerashchenko, Dmitry ^{[1
]}

Wisor, Jonathan P. ^{[1
]}

Burns, Deirdre ^{[1
]}

Reh, Rebecca K. ^{[2
]}

Shiromani, Priyattam J. ^{[3
,4
]}

Sakurai, Takeshi ^{[5
]}

de la Iglesia, Horacio O. ^{[2
]}

Kilduff, Thomas S. ^{[1
]}

机构：

[1] SRI Int, Biosci Div, Menlo Pk, CA 94025 USA

[2] Univ Washington, Dept Biol, Seattle, WA 98195 USA

[3] Vet Adm Med Ctr W Roxbury, Dept Neurol, Boston, MA 02132 USA

[4] Harvard Univ, Sch Med, Boston, MA 02132 USA

[5] Kanazawa Univ, Dept Mol Neurosci & Integrat Phys, Kanazawa, Ishikawa 9208640, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 29期

关键词：

Fos; interneuron; neuronal NOS; sleep deprivation; wakefulness;

D O I：

10.1073/pnas.0803125105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The presence of large-amplitude, slow waves in the EEG is a primary characteristic that distinguishes cerebral activity during sleep from that which occurs during wakefulness. Although sleep-active neurons have been identified in other brain areas, neurons that are specifically activated during slow-wave sleep have not previously been described in the cerebral cortex. We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express neuronal NOS (nNOS). Because Fos expression in these sleep-active, nNOS-immunoreactive (nNOS-ir) neurons parallels changes in the intensity of slow-wave activity in the EEG, and these neurons are innvervated by neurotransmitter systems previously implicated in sleep/wake control, cortical nNOS-it neurons may be part of the neurobiological substrate that underlies homeostatic sleep regulation.

引用

页码：10227 / 10232

页数：6

共 45 条

[31] EXPRESSION OF C-FOS PROTEIN IN BRAIN - METABOLIC MAPPING AT THE CELLULAR-LEVEL [J].