Role of tissue growth factors in aqueous humor homeostasis

被引:52
作者
Welge-Luessen, Ulrich [1 ,2 ]
May, C. Albrecht [2 ]
Neubauer, Aljoscha S. [1 ]
Priglinger, Siegfried [1 ]
机构
[1] Univ Munich, Dept Ophthalmol, D-80336 Munich, Germany
[2] Univ Erlangen Nurnberg, Dept Anat 2, D-91054 Erlangen, Germany
关键词
D O I
10.1097/00055735-200104000-00003
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The aqueous humor supplies nutrients to the nonvascularized cornea, lens, and trabecular meshwork. A number of tissue growth factors have been detected in this fluid. The composition of these proteins changes dramatically with different ocular conditions, such as inflammation and glaucoma. In this review, an overview of new findings regarding effects of aqueous humor growth factors is given. Our main emphasis is on the regulation of the avascular anterior eye compartment, the possible role of growth factors in the pathogenesis of glaucoma, and the importance of growth factors for the special immunosuppressive status of the anterior chamber. (C) 2001 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:94 / 99
页数:6
相关论文
共 63 条
[1]  
Acott TS, 1996, GLAUCOMAS, P281
[2]  
ACOTT TS, 1992, PHARM GLAUCOMA, P125
[3]  
Acott TS, 1994, TXB OPHTHALMOLOGY
[4]   VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].
AIELLO, LP ;
AVERY, RL ;
ARRIGG, PG ;
KEYT, BA ;
JAMPEL, HD ;
SHAH, ST ;
PASQUALE, LR ;
THIEME, H ;
IWAMOTO, MA ;
PARK, JE ;
NGUYEN, HV ;
AIELLO, LM ;
FERRARA, N ;
KING, GL .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487
[5]  
ALEXANDER JP, 1991, INVEST OPHTH VIS SCI, V32, P172
[6]   The lens influences aqueous humor levels of transforming growth factor-β2 [J].
Allen, JB ;
Davidson, MG ;
Nasisse, MP ;
Fleisher, LN ;
McGahan, MC .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1998, 236 (04) :305-311
[7]   Human hepatocyte growth factor (HGF) in the aqueous humor [J].
Araki-Sasaki, K ;
Danjo, S ;
Kawaguchi, S ;
Hosohata, J ;
Tano, Y .
JAPANESE JOURNAL OF OPHTHALMOLOGY, 1997, 41 (06) :409-413
[9]  
BORISUTH NSC, 1992, INVEST OPHTH VIS SCI, V33, P596
[10]  
Bradley JMB, 1998, INVEST OPHTH VIS SCI, V39, P2649