Transcription-independent functions of MYC: regulation of translation and DNA replication

被引：118

作者：

Cole, Michael D. ^{[1
,2
]}

Cowling, Victoria H. ^{[1
,2
,3
]}

机构：

[1] Norris Cotton Canc Ctr, Dept Pharmacol, Dartmouth Med Sch, Lebanon, NH 03756 USA

[2] Norris Cotton Canc Ctr, Dept Genet, Dartmouth Med Sch, Lebanon, NH 03756 USA

[3] Univ Dundee, Div Cell Biol & Immunol, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2467

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

引用

页码：810 / 815

页数：6

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