Targeting IL-17 in psoriasis: From cutaneous immunobiology to clinical application

被引：41

作者：

Ariza, Maria-Eugenia ^{[1
,2
]}

Williams, Marshall V. ^{[1
,2
]}

Wong, Henry K. ^{[3
]}

机构：

[1] Ohio State Univ, Med Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Med Ctr, Inst Behav Med Res, Columbus, OH 43210 USA

[3] Ohio State Univ, Med Ctr, Dept Internal Med, Div Dermatol, Columbus, OH 43210 USA

来源：

CLINICAL IMMUNOLOGY | 2013年 / 146卷 / 02期

关键词：

Psoriasis; IL-17; T cells; T(H)17; Therapy; Inflammation; GENOME-WIDE ASSOCIATION; T-HELPER TYPE-1; DENDRITIC CELLS; SUSCEPTIBILITY LOCUS; MONOCLONAL-ANTIBODY; THERAPEUTIC TARGET; VULGARIS LESIONS; T(H)17 CYTOKINE; INTERLEUKIN; 22; SKIN-LESIONS;

D O I：

10.1016/j.clim.2012.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis vulgaris is a chronic, immune-mediated inflammatory skin disease associated with complex genetic susceptibility. Although the hallmark of psoriasis is characterized by cutaneous inflammation and keratinocyte hyperproliferation, recent studies show that the pathologic features observed in psoriasis arises as a result of innate and adaptive immune activation in genetically prone individuals. Studies focused on the microenvironment in the skin of psoriasis lesions have revealed novel cellular and cytokine abnormalities of the immune system. One pathway important is the role of the T(H)17/IL-17 dysregulation. The recent development of biologics that target the IL-17 cytokine pathway has confirmed the importance of T(H)17 and IL-17 homeostasis in the skin and yielded potent therapies in the treatment of psoriasis, and potentially other autoimmune diseases. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：131 / 139

页数：9

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