Apoptosis in lung injury and fibrosis

被引：132

作者：

Drakopanagiotakis, F. ^{[2
]}

Xifteri, A. ^{[2
]}

Polychronopoulos, V. ^{[2
]}

Bouros, D. ^{[1
]}

机构：

[1] Democritus Univ Thrace, Univ Gen Hosp, Sch Med, Dept Pneumol,Hellen Interstitial Lung Dis Grp, Alexandroupolis 68100, Greece

[2] Sismanoglio Gen Hosp, Dept Pneumol 3, Interstitial Lung Dis Study Grp, Athens, Greece

来源：

EUROPEAN RESPIRATORY JOURNAL | 2008年 / 32卷 / 06期

关键词：

Apoptosis; epithelium; fibroblast; mechanisms; pathogenesis; pulmonary fibrosis;

D O I：

10.1183/09031936.00176807

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary fibrosis, is characterised by fibroblast accumulation and alveolar epithelium denudation. Increased apoptosis of alveolar epithelial cells and decreased apoptosis of fibroblasts may play an important role in the pathogenesis of disease. Inflammatory cells can modulate apoptosis of other cell types, both by removal of apoptotic debris and by cytokine production, thus preserving a pro-fibrotic environment. In the present review, some of the mechanisms by which apoptosis may contribute to the pathogenesis of idiopathic pulmonary fibrosis are described.

引用

收藏

页码：1631 / 1638

页数：8

相关论文

共 87 条

[1] Pathogenetic pathways and novel pharmaco therapeutic targets in idiopathic pulmonary fibrosis [J].

Antomou, Katerma M. ;

Pataka, Athanasia ;

Bouros, Demosthenes ;

Slafakas, Nikolaos M. .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2007, 20 (05) :453-461

[2]

Antoniou KM, 2005, SARCOIDOSIS VASC DIF, V22, P91

[3] Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis [J].

Avivi-Green, Carmel ;

Singal, Mayank ;

Vogel, Wolfgang F. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (04) :420-427

[4] Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis [J].

Baran, Christopher P. ;

Opalek, Judy M. ;

McMaken, Sara ;

Newland, Christie A. ;

O'Brien, James M., Jr. ;

Hunter, Melissa G. ;

Bringardner, Benjamin D. ;

Monick, Martha M. ;

Brigstock, David R. ;

Stromberg, Paul C. ;

Hunninghake, Gary W. ;

Marsh, Clay B. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 176 (01) :78-89

[5] Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways [J].

Beere, HM .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) :2633-2639

[6] Granulocyte apoptosis in the pathogenesis and resolution of lung disease [J].

Bianchi, SM ;

Dockrell, DH ;

Renshaw, SA ;

Sabroe, I ;

Whyte, MKB .

CLINICAL SCIENCE, 2006, 110 (03) :293-304

[7] Telomere length, stem cells and aging [J].

Blasco, Maria A. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (10) :640-649

[8] Pulmonary function and high-resolution CT findings in patients with an inherited form of pulmonary fibrosis, Hermansky-Pudlak syndrome, due to mutations in HPS-1 [J].

Brantly, M ;

Avila, NA ;

Shotelersuk, V ;

Lucero, C ;

Huizing, M ;

Gahl, WA .

CHEST, 2000, 117 (01) :129-136

[9]

Brown SB, 1999, J IMMUNOL, V162, P480

[10] Proapoptotic bid is required for pulmonary fibrosis [J].

Budinger, GRS ;

Mutlu, GM ;

Eisenbart, J ;

Fuller, AC ;

Bellmeyer, AA ;

Baker, CM ;

Wilson, M ;

Ridge, K ;

Barrett, TA ;

Lee, VY ;

Chandel, NS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (12) :4604-4609

← 1 2 3 4 5 6 7 8 9 →