共 164 条
Granulocyte apoptosis in the pathogenesis and resolution of lung disease
被引:49
作者:

Bianchi, SM
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h-index: 0
机构: Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England

Dockrell, DH
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h-index: 0
机构: Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England

Renshaw, SA
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h-index: 0
机构: Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England

Sabroe, I
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机构: Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England

Whyte, MKB
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h-index: 0
机构: Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England
机构:
[1] Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England
[2] Univ Sheffield, Div Genom Med, Acad Unit Infect Dis, Sheffield S10 2JF, S Yorkshire, England
基金:
英国惠康基金;
英国医学研究理事会;
关键词:
apoptosis;
cosinophil;
granulocyte;
inflammation;
lung disease;
neutrophil;
D O I:
10.1042/CS20050178
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
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页码:293 / 304
页数:12
相关论文
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