Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Fadok, VA
;
Bratton, DL
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机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Bratton, DL
;
Guthrie, L
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机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Guthrie, L
;
Henson, PM
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机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Fadok, VA
;
Bratton, DL
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Bratton, DL
;
Guthrie, L
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA
Guthrie, L
;
Henson, PM
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USANatl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA