Granulocyte apoptosis in the pathogenesis and resolution of lung disease

被引:49
作者
Bianchi, SM
Dockrell, DH
Renshaw, SA
Sabroe, I
Whyte, MKB
机构
[1] Univ Sheffield, Royal Hallamshire Hosp, Div Genome Med, Acad Unit Resp Med, Sheffield S10 2JF, S Yorkshire, England
[2] Univ Sheffield, Div Genom Med, Acad Unit Infect Dis, Sheffield S10 2JF, S Yorkshire, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
apoptosis; cosinophil; granulocyte; inflammation; lung disease; neutrophil;
D O I
10.1042/CS20050178
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
引用
收藏
页码:293 / 304
页数:12
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