Dietary protein recommendations and the prevention of sarcopenia

被引:580
作者
Paddon-Jones, Douglas [1 ]
Rasmussen, Blake B. [1 ]
机构
[1] Univ Texas Galveston, Med Branch, Dept Phys Therapy, Div Rehabil Sci, Galveston, TX 77555 USA
关键词
ageing; leucine; muscle protein synthesis; protein intake; sarcopenia; ESSENTIAL AMINO-ACIDS; SKELETAL-MUSCLE; RESISTANCE EXERCISE; LEAN MASS; ANABOLIC RESPONSE; NITROGEN-BALANCE; ELDERLY HUMANS; OLDER-PEOPLE; BED REST; LEUCINE;
D O I
10.1097/MCO.0b013e32831cef8b
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing. Recent findings Ageing does not inevitably reduce the anabolic response to a high-quality protein meal. Ingestion of approximately 25-30 g of protein per meal maximally stimulates muscle protein synthesis in both young and older individuals. However, muscle protein synthesis is blunted in elderly when protein and carbohydrate are coingested or when the quantity of protein is less than approximately 20 g per meal. Supplementing regular mixed-nutrient meals with leucine may also enhance the muscle protein synthetic response in elders. Summary On the basis of recent work, we propose a novel and specific dietary approach to prevent or slow down muscle loss with ageing. Rather than recommending a large, global increase in the recommended dietary allowance (RDA) for protein for all elderly individuals, clinicians should stress the importance of ingesting a sufficient amount of protein with each meal. To maximize muscle protein synthesis while being cognizant of total energy intake, we propose a dietary plan that includes 25-30 g of high quality protein per meal.
引用
收藏
页码:86 / 90
页数:5
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