An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones

被引：44

作者：

Chen, Chengqun ^{[1
]}

Feng, Xinghua ^{[1
]}

Zhang, Guozhen ^{[1
]}

Zhao, Qin ^{[1
]}

Huang, Guosheng ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2008年 / 20期

关键词：

Oxone (R); hydroxylation; iodobenzene; alpha-hydroxy ketones;

D O I：

10.1055/s-0028-1083149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exposure of alkyl aryl ketones to Oxone (R)/trifluoroacetic anhydride in the presence of a catalytic amount of iodobenzene affords alpha-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the installation of alpha-hydroxy moieties into ketones and should find wide application in the construction of the a-hydroxy ketone subunit in natural product synthesis.

引用

页码：3205 / 3208

页数：4

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