Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

被引：345

作者：

Hall, A. R. ^{[1
]}

Burke, N. ^{[1
]}

Dongworth, R. K. ^{[1
]}

Hausenloy, D. J. ^{[1
]}

机构：

[1] Univ Coll London Hosp & Med Sch, Hatter Cardiovasc Inst, Inst Cardiovasc Sci, NIHR Univ Coll London Hosp Biomed Res Ctr, London WC1E 6HX, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2014年 / 171卷 / 08期

基金：

英国医学研究理事会;

关键词：

mitochondrial fusion; mitochondrial fission; MFN1; MFN2; Drp1; OPA1; mitochondrial morphology; mitochondrial dynamics; DYNAMIN-RELATED PROTEIN-1; CYTOCHROME-C RELEASE; PERMEABILITY TRANSITION PORE; ENDOPLASMIC-RETICULUM; MITOFUSIN; INDUCED PHOSPHORYLATION; CARDIAC-HYPERTROPHY; DOWN-REGULATION; CELL-DEATH; OPA1;

D O I：

10.1111/bph.12516

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases. Linked ArticlesThis article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit

引用

页码：1890 / 1906

页数：17

共 133 条

[1]

Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria [J].

An, Hyun-Jung ;

Cho, Geunyoung ;

Lee, Jie-Oh ;

Paik, Sang-Gi ;

Kim, Young Sang ;

Lee, Hayyoung .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (32) :13014-13019

[2]

[Anonymous], 2012, PLOS ONE, DOI DOI 10.1186/2045-3701-2-40

[3]

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy [J].

Ashrafian, Houman ;

Docherty, Louise ;

Leo, Vincenzo ;

Towlson, Christopher ;

Neilan, Monica ;

Steeples, Violetta ;

Lygate, Craig A. ;

Hough, Tertius ;

Townsend, Stuart ;

Williams, Debbie ;

Wells, Sara ;

Norris, Dominic ;

Glyn-Jones, Sarah ;

Land, John ;

Barbaric, Ivana ;

Lalanne, Zuzanne ;

Denny, Paul ;

Szumska, Dorota ;

Bhattacharya, Shoumo ;

Griffin, Julian L. ;

Hargreaves, Iain ;

Fernandez-Fuentes, Narcis ;

Cheeseman, Michael ;

Watkins, Hugh ;

Dear, T. Neil .

PLOS GENETICS, 2010, 6 (06) :1-18

[4]

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter [J].

Baughman, Joshua M. ;

Perocchi, Fabiana ;

Girgis, Hany S. ;

Plovanich, Molly ;

Belcher-Timme, Casey A. ;

Sancak, Yasemin ;

Bao, X. Robert ;

Strittmatter, Laura ;

Goldberger, Olga ;

Bogorad, Roman L. ;

Koteliansky, Victor ;

Mootha, Vamsi K. .

NATURE, 2011, 476 (7360) :341-U111

[5]

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria [J].

Cereghetti, G. M. ;

Stangherlin, A. ;

de Brito, O. Martins ;

Chang, C. R. ;

Blackstone, C. ;

Bernardi, P. ;

Scorrano, L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) :15803-15808

[6]

Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition [J].

Cerqua, Cristina ;

Anesti, Vassiliki ;

Pyakurel, Aswin ;

Liu, Dan ;

Naon, Deborah ;

Wiche, Gerhard ;

Baffa, Raffaele ;

Dimmer, Kai S. ;

Scorrano, Luca .

EMBO REPORTS, 2010, 11 (11) :854-860

[7]

Mitochondrial Motility and Vascular Smooth Muscle Proliferation [J].

Chalmers, Susan ;

Saunter, Christopher ;

Wilson, Calum ;

Coats, Paul ;

Girkin, John M. ;

McCarron, John G. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (12) :3000-+

[8]

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology [J].

Chang, Chuang-Rung ;

Blackstone, Craig .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (30) :21583-21587

[9]

Disruption of fusion results in mitochondrial heterogeneity and dysfunction [J].

Chen, HC ;

Chomyn, A ;

Chan, DC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (28) :26185-26192

[10]

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [J].

Chen, HC ;

Detmer, SA ;

Ewald, AJ ;

Griffin, EE ;

Fraser, SE ;

Chan, DC .

JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :189-200

← 1 2 3 4 5 6 7 8 9 10 →