CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis

被引：32

作者：

Alaaeddine, Nada ^{[2
]}

Hassan, Ghada S. ^{[1
]}

Yacoub, Daniel ^{[1
]}

Mourad, Walid ^{[1
]}

机构：

[1] Hop St Luc, Lab Immunol Cellulaire & Mol, Ctr Hosp Univ Montreal, Montreal, PQ H2X 1P1, Canada

[2] St Joseph Univ, Dept Pathol, Fac Med, Beirut, Lebanon

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

基金：

加拿大健康研究院;

关键词：

SOLUBLE CD40 LIGAND; NECROSIS-FACTOR-ALPHA; COLLAGEN-INDUCED ARTHRITIS; INTEGRIN MAC-1 CD11B/CD18; T-CELLS; CD40-CD40; LIGAND; B-CELLS; INTERLEUKIN-12; PRODUCTION; INCREASED EXPRESSION; ANTI-CD40;

D O I：

10.1155/2012/490148

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus and rheumatoid arthritis are two major chronic inflammatory autoimmune diseases with significant prevalence rates among the population. Although the etiology of these diseases remains unresolved, several evidences support the key role of CD154/CD40 interactions in initiating and/or propagating these diseases. The discovery of new receptors (alpha II beta 3, alpha 5 beta 1, and alpha M beta 2) for CD154 has expanded our understanding about the precise role of this critical immune mediator in the physiopathology of chronic inflammatory autoimmune diseases in general, and in systemic lupus erythematosus and rheumatoid arthritis in particular. This paper presents an overview of the interaction of CD154 with its various receptors and outlines its role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis. Moreover, the potential usefulness of various CD154-interfering agents in the treatment and prevention of these diseases is also discussed.

引用

页数：11

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