Acute stress exposure prior to influenza vaccination enhances antibody response in women

被引:114
作者
Edwards, KM [1 ]
Burns, VE
Reynolds, T
Carroll, D
Drayson, M
Ring, C
机构
[1] Univ Birmingham, Sch Sport & Exercise Sci, Birmingham, W Midlands, England
[2] Univ Birmingham, Sch Med, Dept Immunol, Birmingham, W Midlands, England
关键词
acute stress; antibody; cortisol; influenza vaccination; interleukin-6;
D O I
10.1016/j.bbi.2005.07.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Animal studies have shown that an acute stressor in close temporal proximity to immune challenge can enhance the response to delayed-type hypersensitivity and antibody response to vaccination. The current study examined the effects of acute exercise or mental stress prior to influenza vaccination on the subsequent antibody response to each of the three viral strains. Sixty young healthy adults (31 men, 29 women) were randomly allocated to one of three task conditions: dynamic exercise, mental stress, or control. After an initial baseline, participants completed their allocated 45 min task and then received the influenza vaccine. Plasma cortisol and interleukin-6 were determined at the end of baseline, after the task, and after 60 min recovery. Antibody titres were measured prevaccination and at 4 weeks and 20 weeks post-vaccination follow-ups. For the A/Panama strain, women in both the exercise and mental stress conditions showed higher antibody titres at both 4 and 20 weeks than those in the control condition, while men responded similarly in all conditions. Interleukin-6 at +60 min recovery was found to be a significant predictor of subsequent A/Panama antibody response in women. In line with animal research, the current study provides preliminary evidence that acute stress can enhance the antibody response to vaccination in humans. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:159 / 168
页数:10
相关论文
共 51 条
  • [1] ADER R, 2001, PSYCHONEUROIMMUNOLOG, V1
  • [2] Sex-associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines
    Atabani, S
    Landucci, G
    Steward, MW
    Whittle, H
    Tilles, JG
    Forthal, DN
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2000, 7 (01) : 111 - 113
  • [3] BLECHA F, 1982, P SOC EXP BIOL MED, V169, P239
  • [4] BLECHA F, 1982, P SOC EXP BIOL MED, V169, P247
  • [5] Bosch JA, 2002, INT REV NEUROBIOL, V52, P213
  • [6] In vivo cell mediated immunity and vaccination response following prolonged, intense exercise
    Bruunsgaard, H
    Hartkopp, A
    Mohr, T
    Konradsen, H
    Heron, I
    Mordhorst, CH
    Pedersen, BK
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1997, 29 (09) : 1176 - 1181
  • [7] Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults
    Burns, VE
    Carroll, D
    Drayson, M
    Whitham, M
    Ring, C
    [J]. JOURNAL OF PSYCHOSOMATIC RESEARCH, 2003, 55 (06) : 569 - 572
  • [8] Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms
    Burns, VE
    Carroll, D
    Ring, C
    Drayson, M
    [J]. VACCINE, 2003, 21 (19-20) : 2523 - 2534
  • [9] Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: A preliminary study
    Burns, VE
    Ring, C
    Drayson, M
    Carroll, D
    [J]. PSYCHOPHYSIOLOGY, 2002, 39 (03) : 361 - 368
  • [10] A GLOBAL MEASURE OF PERCEIVED STRESS
    COHEN, S
    KAMARCK, T
    MERMELSTEIN, R
    [J]. JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1983, 24 (04) : 385 - 396