Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics

被引：85

作者：

Akbar, D. H. ^{[1
]}

Ahmed, M. M. ^{[1
]}

Al-Mughales, J. ^{[1
]}

机构：

[1] King Abdulaziz Univ Hosp, Jeddah, Saudi Arabia

来源：

ACTA DIABETOLOGICA | 2006年 / 43卷 / 01期

关键词：

thyroid dysfunction; type; 2; diabetes; GAD65ab; thyroid autoimmunity; Saudi;

D O I：

10.1007/s00592-006-0204-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus and thyroid disease are common endocrine disorders in the general population. To investigate the association between thyroid dysfunction, thyroid autoimmunity and Saudi type 2 diabetics, a random sample of 100 Saudi type 2 diabetics and 100 age- and sex-matched controls were studied. The mean age was 54 years for diabetics and 55 years for controls while the male:female ratios were 1:1.6 and 1:14 respectively. GAD65ab were found in 26% diabetics and 2% controls (p=0.001). Thyroid autoimmunity were detected in 10% diabetics vs. 5% controls (p=0.05), while thyroid dysfunction was found in 16% and 7% respectively (p=0.03). In GAD65ab-positive diabetics, thyroid autoimmunity was observed in 27% vs. 4% GAD65ab-negative diabetics (p=0.02) and thyroid dysfunction was reported in 42% and 7% respectively. We conclude that thyroid dysfunction and autoimmunity are common in Saudi type 2 diabetics. Further studies are needed on the cost effectiveness of thyroid screening in diabetics.

引用

页码：14 / 18

页数：5

共 35 条

[1]

ALNUAIM AR, 1995, NATL CHRONIC METAB 1, P1

[2] Time to declare war on diabetes [J].