Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest

被引：109

作者：

Selig, L

Benichou, S

Rogel, ME

Wu, LI

Vodicka, MA

Sire, J

Benarous, R

Emerman, M

机构：

[1] INSERM U372, F-13276 MARSEILLE 9, FRANCE

[2] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98109 USA

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 06期

关键词：

D O I：

10.1128/JVI.71.6.4842-4846.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G(2) arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodeficiency virus of sooty mangabeys (STVSM) bind the DNA repair enzyme UNG, while the Vpx protein of SIVSM does not. Nonetheless, a mutational analysis of Vpr showed that binding to UNG is neither necessary nor sufficient for the effect of Vpr on the cell cycle.

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收藏

页码：4842 / 4846

页数：5

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