Network stability from activity-dependent regulation of neuronal conductances

被引:128
作者
Golowasch, J [1 ]
Casey, M
Abbott, LF
Marder, E
机构
[1] Brandeis Univ, Volen Ctr, Waltham, MA 02454 USA
[2] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
关键词
D O I
10.1162/089976699300016359
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Activity-dependent plasticity appears to play an important role in the modification of neurons and neural circuits that occurs during development and learning. Plasticity is also essential for the maintenance of stable patterns of activity in the face of variable environmental and internal conditions. Previous theoretical and experimental results suggest that neurons stabilize their activity by altering the number or characteristics of ion channels to regulate their intrinsic electrical properties. We present both experimental and modeling evidence to show that activity-dependent regulation of conductances, operating at the level of individual neurons, can also stabilize network activity. These results indicate that the stomatogastric ganglion of the crab can generate a characteristic rhythmic pattern of activity in two fundamentally different modes of operation. In one mode, the rhythm is strictly conditional on the presence of neuromodulatory afferents from adjacent ganglia. In the other, it is independent of neuromodulatory input but relies on newly developed intrinsic properties of the component neurons.
引用
收藏
页码:1079 / 1096
页数:18
相关论文
共 29 条
[1]   ANALYSIS OF NEURON MODELS WITH DYNAMICALLY REGULATED CONDUCTANCES [J].
ABBOTT, LF ;
LEMASSON, G .
NEURAL COMPUTATION, 1993, 5 (06) :823-842
[2]   CALCIUM-MEDIATED REDUCTION OF IONIC CURRENTS - A BIOPHYSICAL MEMORY TRACE [J].
ALKON, DL .
SCIENCE, 1984, 226 (4678) :1037-1045
[3]   LONG-TERM DEPRESSION OF EXCITATORY SYNAPTIC TRANSMISSION AND ITS RELATIONSHIP TO LONG-TERM POTENTIATION [J].
ARTOLA, A ;
SINGER, W .
TRENDS IN NEUROSCIENCES, 1993, 16 (11) :480-487
[4]   Ca2+-dependent regulation in neuronal gene expression [J].
Bito, H ;
Deisseroth, K ;
Tsien, RW .
CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :419-429
[5]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[6]   Genetic analysis of synaptic development and plasticity: homeostatic regulation of synaptic efficacy [J].
Davis, GW ;
Goodman, CS .
CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (01) :149-156
[7]  
FRANKLIN JL, 1992, J NEUROSCI, V12, P1726
[8]  
GOLOWASCH J, 1992, J NEUROSCI, V12, P810
[9]   CONTRIBUTION OF INDIVIDUAL IONIC CURRENTS TO ACTIVITY OF A MODEL STOMATOGASTRIC GANGLION NEURON [J].
GOLOWASCH, J ;
BUCHHOLTZ, F ;
EPSTEIN, IR ;
MARDER, E .
JOURNAL OF NEUROPHYSIOLOGY, 1992, 67 (02) :341-349
[10]   Characterization of a P-type calcium current in a crayfish motoneuron and its selective modulation by impulse activity [J].
Hong, SJ ;
Lnenicka, GA .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 77 (01) :76-85