Inhibitory effect of the intravenous anesthetic, ketamine, on rat mesangial cell proliferation

被引:28
作者
Jimi, N
Segawa, K
Minami, K
Sata, T
Shigematsu, A
机构
[1] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 2,KITAKYUSHU,FUKUOKA 807,JAPAN
[2] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT ANESTHESIOL,KITAKYUSHU,FUKUOKA 807,JAPAN
关键词
D O I
10.1097/00000539-199701000-00034
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We studied the effects of ketamine and propofol on rat cultured mesangial cell (MC) proliferation. The 72-hexposure to ketamine (1-100 mu M) inhibited [H-3]thymidine incorporation into the MC in a concentration-dependent manner. Propofol, however, was not effective at inhibition of MC proliferation at doses from 1 to 100 mu M. Ketamine also decreased the cell number at clinically relevant concentrations and increased adenosine 3',5'-cyclic monophosphate (cAMP) levels in MC. We also studied the effects of ketamine on cytokine-induced [H-3]thymidine incorporation info the cells. Ketamine decreased the tumor necrosis factor-alpha (TNF-alpha)-, interleukin 1 (IL-1)-, and interleukin 6 (IL-6)- induced [H-3]thymidine incorporation into the cells. It also decreased angiotensin II (Ag II)-induced [H-3]thymidine incorporation. These results suggest that ketamine has inhibitory effects on MC proliferation, but that propofol does not. Because ketamine inhibits TNF-alpha-, IL-1-, and IL-6-induced MC proliferation, it may be useful in suppressing the cell growth clinically.
引用
收藏
页码:190 / 195
页数:6
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