Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice

被引：92

作者：

Ge, Yan ^{[1
,2
]}

Xi, Hong ^{[1
]}

Ju, Songguang ^{[1
,2
]}

Zhang, Xueguang ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Med, Dept Immunol, Suzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Clin Immunol, Suzhou, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2013年 / 336卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DC vaccine; PD-L1; Immune checkpoints; Breast cancer; T-CELL APOPTOSIS; ANTITUMOR IMMUNITY; PD-L1; EXPRESSION; DENDRITIC CELLS; IMMUNOTHERAPY; TOLERANCE; CARCINOMA; ANTIBODY; SAFETY;

D O I：

10.1016/j.canlet.2013.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoints, such as the PD-1/PD-L1 pathway, negatively interfere in the efficiency of dendritic cell (DC) vaccination in cancer immunotherapy. In this study, we demonstrated that the blockade of PD-L1 signaling could promote DC maturation, proliferation, and IL-12 secretion, augment DC primed T cell response and reverse tumor cell dampened T cell impairment. Blockade of PD-L1 signaling during DC vaccination showed better therapeutic effects than classic DC vaccination by preventing tumor growth and prolonging survival times in a breast tumor-bearing hu-SCID model. Taken together, suppressing immune checkpoints during DC vaccination might be a more efficient strategy for cancer therapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：253 / 259

页数：7

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