Mechanistic alternatives in Lewis acid-catalyzed acyl halide-aldehyde cyclocondensations

被引：23

作者：

Nelson, SG ^{[1
]}

Peelen, TJ ^{[1
]}

Wan, ZH ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15206 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 36期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(99)01309-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An investigation of the operative reaction mechanisms in Lewis acid-catalyzed acyl halide-aldehyde cyclocondensations is presented. Aluminum-based catalysts promote cyclocondensation via a ketene-dependent reaction pathway while acyl halide enolates are implicated as reactive intermediates in Ti(IV)-catalyzed reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6541 / 6543

页数：3

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